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Target intelligence / Profile preview
Membrane-bound Alkaline Phosphatase (ALP)
- Target
- ALP
- Molecular classification
- Enzyme, Hydrolase, Glycoprotein
01
Overview
Membrane-bound alkaline phosphatase (ALP) is a family of membrane-associated glycoprotein enzymes that catalyze the hydrolysis of phosphate monoesters, releasing inorganic phosphate. ALPs are present in virtually all forms of life and are concentrated in tissues such as liver, bone, kidney, intestinal mucosa, placenta, and germ cells. Serum levels of specific ALP isoenzymes serve as biomarkers for various conditions.
- Other names
- Alkaline PhosphataseALPIALPLALPPALPGIntestinal Alkaline PhosphataseTissue-nonspecific Alkaline PhosphatasePlacental Alkaline PhosphataseGerm cell Alkaline Phosphatase
02
Mechanism of action
Hydrolyzes phosphate monoesters, releasing inorganic phosphate.
03
Biological functions
DephosphorylationBone mineralizationIntestinal absorptionDetoxificationHydrolysis of phosphate esters
04
Disease associations
CholestasisBone disordersLiver diseasesKidney diseasesCancer
05
Safety considerations
Elevated levels can indicate underlying diseaseInhibition can disrupt normal physiological processes
06
Biomarkers
Elevated ALP levels in serumSpecific ALP isoenzyme levels
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