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Target intelligence / Profile preview
Intestinal Alkaline Phosphatase (IAP)
- Target
- IAP
- Molecular classification
- Enzyme, Phosphatase, Ectoenzyme
01
Overview
Intestinal alkaline phosphatase (IAP) is an enzyme expressed in the small intestine by enterocytes. It plays a crucial role in maintaining intestinal homeostasis, protecting gut barrier integrity, and regulating interactions between diet, microbiota, and host immunity. Its primary functions include dephosphorylation of various substrates such as lipopolysaccharide (LPS), flagellin, CpG DNA, ATP/ADP, and other nucleotide di-/tri-phosphates. Deficiency is linked to several gastrointestinal disorders. IAP is also used in drug delivery for phosphate prodrug cleavage.
- Other names
- ALPIAlkaline Phosphatase, Intestinal
02
Mechanism of action
Phosphate prodrug cleavage on mucosal surfaces to release active drugs.
03
Biological functions
DephosphorylationDetoxificationpH regulationFat absorptionMicrobiome regulationGut barrier integrity
04
Disease associations
Inflammatory Bowel Disease (IBD)Necrotizing EnterocolitisMetabolic SyndromeType 2 Diabetes MellitusIschemic Heart DiseaseAging-related pathologies
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