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Target intelligence / Profile preview
Intestinal alpha-glucosidase
- Molecular classification
- Enzyme, Hydrolase, Glycoside Hydrolase, GH31 family
01
Overview
Intestinal alpha-glucosidase is a membrane-bound enzyme located in the brush border of the small intestine. It hydrolyzes terminal, non-reducing (1→4)-linked α-glucose residues from oligosaccharides, trisaccharides, and disaccharides to release single α-glucose molecules for absorption. Inhibitors are used to manage type 2 diabetes.
- Other names
- Alpha-glucosidaseMaltase glucoamylaseSucrase-isomaltase
02
Mechanism of action
Competitive inhibition of alpha-glucosidase, delaying carbohydrate breakdown and glucose absorption.
03
Biological functions
Carbohydrate digestionHydrolysis of oligosaccharides and disaccharidesGlucose releaseIntestinal glucose absorption
04
Disease associations
Type 2 diabetes mellitus
05
Safety considerations
Gastrointestinal side effects (flatulence, diarrhea) due to undigested carbohydrates.
06
Interacting drugs
Acarbose
2 more in the full profile.
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