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Intestinal Chloride Channel
- Molecular classification
- Ion channel, Transporter, Chloride channel, ATP-binding cassette transporter
01
Overview
Intestinal chloride channels are integral membrane proteins located primarily on the apical surface of epithelial cells lining the intestine. Their main function is to mediate the secretion of chloride ions (Cl-) into the intestinal lumen, driving water movement into the gut by osmosis. Major types include CFTR, ClC-2, and CaCCs, each regulated by different signaling pathways and playing distinct roles in intestinal fluid balance and motility. They are therapeutic targets for gastrointestinal disorders like constipation and diarrhea.
- Other names
- CFTRClC-2CLCN2CaCCsCalcium-activated Chloride ChannelsTMEM16A/ANO1
02
Mechanism of action
Agonists increase chloride secretion into the intestinal lumen, while antagonists decrease it.
03
Biological functions
Chloride transportFluid secretionElectrolyte balanceRegulation of intestinal motilityOsmotic regulation
04
Disease associations
Cystic fibrosisDiarrheaConstipationIrritable Bowel Syndrome (IBS)
05
Safety considerations
Over-activation can lead to secretory diarrhea.Inhibition can lead to constipation or exacerbate cystic fibrosis symptoms.Potential for electrolyte imbalance
06
Interacting drugs
Lubiprostone
1 more in the full profile.
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