Intestinal enterocyte villus mannose residues

Intestinal enterocyte villus mannose residues are high-mannose glycans located on the apical surface of intestinal epithelial cells. These carbohydrate structures serve as critical attachment points for various pathogens, most notably Adherent-Invasive Escherichia coli (AIEC) and Uropathogenic Escherichia coli (UPEC), which utilize the FimH adhesin to bind to these residues [1, 2]. This interaction facilitates bacterial colonization, invasion of the gut wall, and the subsequent inflammatory cascade characteristic of diseases like Crohn's disease [3, 10]. In pharmacological contexts, these residues are targeted by anti-adhesive agents such as Sibofimloc (EB8018) or D-mannose, which act as competitive inhibitors to block bacterial binding [5, 11]. By preventing the attachment of pro-inflammatory bacteria to the intestinal lining, these therapies aim to reduce mucosal inflammation and maintain gut homeostasis without disrupting the commensal microbiome [6, 8].

Other names

High-mannose glycansMannosylated glycoproteinsEnterocyte surface mannoseIntestinal epithelial mannose residuesHigh-mannose oligosaccharides

Competitive inhibition of bacterial adhesin (FimH) binding to host cell surface mannose residues, preventing bacterial colonization and invasion.