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Intestinal Epithelial Barrier (IEB)
- Target
- IEB
- Molecular classification
- Multicellular Structure, Epithelium, Barrier
01
Overview
The intestinal epithelial barrier is a complex, multicellular structure that separates the intestinal lumen from the underlying tissues. It consists of a single layer of epithelial cells connected by tight junctions, a mucus layer, and an underlying lamina propria containing immune cells. Its primary function is to selectively allow nutrient absorption while preventing the passage of harmful substances and pathogens. Disruption of this barrier, often referred to as "leaky gut," is implicated in various gastrointestinal and systemic diseases.
- Other names
- Gut barrierIntestinal barrierEpithelial barrier
02
Mechanism of action
Restoration of barrier integrity, modulation of tight junctions, enhancement of mucus production, modulation of gut microbiota
03
Biological functions
Selective absorptionBarrier functionImmune regulationAntimicrobial defenseHomeostasis maintenance
04
Disease associations
Inflammatory bowel disease (IBD)Celiac diseaseIrritable bowel syndrome (IBS)Colon cancerChronic liver diseaseType I diabetes mellitusObesityLeaky gut syndrome
05
Safety considerations
Potential for systemic immune activationAlterations in gut microbiota compositionOff-target effects on other epithelial barriers
06
Biomarkers
ZonulinIntestinal fatty acid binding protein (I-FABP)Lipopolysaccharide (LPS)sCD14
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