Intestinal epithelial cell surface mannose-containing glycoproteins

Intestinal epithelial cell surface mannose-containing glycoproteins are a group of membrane-bound proteins characterized by the presence of mannose-rich oligosaccharide chains, with Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) being the most prominent member (Barnich et al., J Clin Invest, 2007). These glycoproteins are primarily located on the apical surface of enterocytes and play physiological roles in cell-cell adhesion and innate immune signaling (Sivignon et al., Expert Rev Gastroenterol Hepatol, 2015). In pathological conditions such as Crohn's disease, their expression is significantly upregulated, particularly in the ileal mucosa, where they serve as receptors for the FimH adhesin of Adherent-Invasive Escherichia coli (AIEC) (Spaeth et al., PLoS One, 2013). This pathogen-host interaction facilitates bacterial colonization, invasion, and the subsequent inflammatory response characteristic of inflammatory bowel disease. Therapeutic strategies, such as the use of D-mannose or the FimH antagonist Sibofimloc (EB8018), aim to competitively inhibit this binding, thereby preventing bacterial attachment and reducing mucosal inflammation (Enterome, 2023). These glycoproteins represent a critical interface for host-microbe interactions and a novel focal point for anti-adhesive therapies in gastroenterology.

Other names

Mannosylated intestinal glycoproteinsMannose-containing glycoconjugatesCEACAM6CD66cCarcinoembryonic antigen-related cell adhesion molecule 6

Competitive inhibition of bacterial FimH adhesin binding to host mannose-containing glycoproteins