Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Intestinal Epithelium Regeneration (IER)
- Target
- IER
- Molecular classification
- Cellular Process, Tissue Regeneration, Homeostasis
01
Overview
Intestinal epithelium regeneration is the process by which the lining of the intestine is continuously renewed and repaired. This process is essential for maintaining gut health, nutrient absorption, and barrier function. It involves the proliferation and differentiation of intestinal stem cells (ISCs), the activation of reserve stem cells upon injury, and potentially the dedifferentiation of mature epithelial cells. Key signaling pathways such as Wnt/β-catenin and Notch regulate this process. Impaired regeneration contributes to various diseases, including IBD and cancer.
- Other names
- Intestinal Epithelial RepairGut Lining RegenerationIntestinal Mucosal Healing
02
Mechanism of action
N/A
03
Biological functions
Tissue RepairBarrier MaintenanceNutrient AbsorptionImmune HomeostasisCell ProliferationCell DifferentiationCell Migration
04
Disease associations
Inflammatory Bowel Disease (IBD)Celiac DiseaseShort Bowel SyndromeInfection RecoveryColorectal CancerEpithelial InjuryMucositis
05
Safety considerations
Dysregulation leading to tumorigenesisExcessive regeneration causing fibrosisIncomplete regeneration leading to chronic inflammationPotential for drug-induced damageRisk of infection during regenerationDevelopment of dysplasia
06
Interacting drugs
Growth factors (e.g., EGF, TGF-β)
5 more in the full profile.
07
Biomarkers
LGR5 expressionOLFM4 expressionKi-67 proliferation markerEpithelial barrier function markers (e.g., transepithelial electrical resistance, permeability)Stem cell gene expression signaturesCytokine levels (e.g. IL-10, TNF alpha)
Beyond the preview
Go deeper on Intestinal Epithelium Regeneration (IER).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Intestinal Epithelium Regeneration (IER).