Intestinal Glucose Absorption Transporter System

The intestinal glucose absorption transporter system is a complex network of proteins, primarily SGLT1 and GLUT2, responsible for the uptake of glucose from the intestinal lumen into enterocytes and its subsequent release into the bloodstream. SGLT1 mediates active transport of glucose with sodium, while GLUT2 facilitates passive diffusion. This system is critical for maintaining glucose homeostasis, and alterations can lead to diseases such as glucose-galactose malabsorption, diabetes, and obesity.

Other names

Intestinal Glucose Transporter SystemGlucose Absorption SystemIntestinal Sugar TransportersEnterocyte Glucose Uptake System

SGLT1 inhibitors block the reabsorption of glucose in the kidney and intestine, promoting its excretion in the urine and reducing blood glucose levels. This reduces glucose absorption from intestine. Some agents also affect incretin hormone secretion.