Intestinal microbial community structure restoration

"Intestinal microbial community structure restoration" refers to therapeutic approaches—such as dietary changes, probiotics, prebiotics, synbiotics, antibiotics (followed by restoration), and especially fecal microbiota transplant (FMT)—that aim to restore a healthy balance and diversity in the gut microbiota. This restoration is associated with improvements in conditions linked to dysbiosis, such as recurrent *Clostridioides difficile* infection, irritable bowel syndrome, metabolic diseases, inflammatory bowel diseases, and some autoimmune and malignancy risk. The target is not a molecule but rather the overall structure and composition of the microbial community within the gut. There is no unique molecular identifier, and the phrase should not be considered a molecular drug target.

Other names

Gut microbiota restorationRestoration of gut microbial communityGut microbiome modulationMicrobiome reconstitutionMicrobial community normalization

Restoration or augmentation of commensal microbial populations; Suppression of pathogenic or dysbiotic taxa; Enhancement of beneficial metabolite production (e.g. SCFAs); Improvement of host immune tolerance; Modulation of bile acid metabolism