Intestinal microbiota and skin barrier function

The "intestinal microbiota and skin barrier function" describes the complex bidirectional relationship between the gut microbial community and the physiological function of the skin barrier. The gut microbiota influences skin health through systemic immune modulation, production of metabolic mediators (such as short-chain fatty acids and microbial polysaccharides), and maintenance of immune homeostasis. Disruption of this axis, termed gut-skin dysbiosis, is associated with various dermatological conditions, including atopic dermatitis, psoriasis, and acne. Interventions such as probiotics, prebiotics, and microbiome-modulating therapeutics show potential for fortifying the skin barrier and mitigating disease. However, this is not a single molecular target, but an interaction between complex systems, making it unsuitable as a canonical drug target in a molecular sense[1][2][4].

Other names

Gut-skin axisGut microbiome and skin barrierMicrobiota-skin barrier interaction

Modulation of immune responses (e.g., T-cell differentiation) Production of metabolites (short-chain fatty acids, polysaccharide A) influencing skin inflammation and barrier integrity Enhancement of circulating cytokines beneficial for skin barrier (e.g., TGF-β) Restoration of microbiome balance