Intestinal microbiota restoration

Intestinal microbiota restoration refers to therapeutic interventions, such as fecal microbiota transplantation and microbiota restoration therapies, designed to re-establish a healthy balance and diversity of the gut microbiome. It is primarily used to treat recurrent Clostridioides difficile infection, is under investigation for other gastrointestinal and immune-mediated diseases, and functions by introducing beneficial microbes to outcompete pathogens, restore metabolic and immune functions, and enable gut homeostasis. This field is evolving, with approaches ranging from whole-stool transplantation to defined bacterial consortia and targeted small molecules or phage therapy, but "intestinal microbiota restoration" is a therapeutic principle, not a molecular or protein drug target.

Other names

Microbiota restorationMicrobiota restoration therapyGut microbiota restorationFecal microbiota restorationMicrobiome restoration

Engraftment of beneficial microbial taxa to displace pathogenic microorganisms; Restoration of microbial diversity and functions; Inhibition of antibiotic-resistant organisms; Increase in beneficial metabolite production (e.g., short-chain fatty acids); Immune system modulation