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Target intelligence / Profile preview
Intestinal Microflora (Gut Microbiota)
- Target
- Gut Microbiota
- Molecular classification
- Microbial Community, Ecosystem
01
Overview
Intestinal microflora, also known as gut microbiota or gut flora, refers to the complex community of microorganisms—including bacteria, archaea, viruses, and fungi—that inhabit the human gastrointestinal (GI) tract. This ecosystem is highly dynamic and varies between individuals and across different regions of the GI tract. It plays a crucial role in digestion, immunity, pathogen defense, and overall health. Dysbiosis, or imbalance in the gut microbiota, is associated with various diseases.
- Other names
- Gut FloraIntestinal MicrobiomeHuman Gut Microbiota
02
Mechanism of action
Varies depending on intervention. Antibiotics disrupt the microbiota. Probiotics introduce beneficial bacteria. Prebiotics promote growth of beneficial bacteria. FMT replaces the existing microbiota with a donor's microbiota.
03
Biological functions
Digestion and MetabolismImmune System Development and RegulationPathogen Resistance (Colonization Resistance)Maintenance of Gut Barrier IntegrityXenobiotic and Drug MetabolismVitamin Synthesis
04
Disease associations
Inflammatory Bowel Disease (IBD)ObesityType 2 Diabetes MellitusAllergiesInfectionsMetabolic SyndromeNeurological Disorders (via Gut-Brain Axis)Pulmonary Diseases (via Gut-Lung Axis)
05
Safety considerations
Antibiotic-associated dysbiosisRisk of infection with FMTUnpredictable effects of probiotics/prebiotics in certain individualsPotential for transfer of antibiotic resistance genes
06
Interacting drugs
Antibiotics
3 more in the full profile.
07
Biomarkers
Bacterial Composition (e.g., relative abundance of Bacteroidetes and Firmicutes)Short-Chain Fatty Acid (SCFA) levels (e.g., butyrate, acetate, propionate)Presence/Absence of specific bacterial speciesMicrobial Diversity (e.g., Shannon diversity index)
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