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Intestinal Barrier Function
- Molecular classification
- Multi-component system, Epithelial barrier, Immune barrier, Microbial barrier
01
Overview
The intestinal barrier function is a complex, multi-layered system that selectively allows the absorption of nutrients while preventing the entry of harmful substances into the bloodstream. It comprises the epithelial cell layer connected by tight junctions, the gut microbiota, and the gut-associated lymphoid tissue (GALT). Dysfunction of the intestinal barrier, often referred to as "leaky gut," is implicated in various diseases due to increased permeability and translocation of bacteria and toxins.
- Other names
- Gut barrierIntestinal permeabilityGut integrity
02
Mechanism of action
Varied, depending on the specific drug/intervention. Includes modulation of tight junction proteins, promotion of beneficial microbiota, reduction of inflammation, and direct barrier-protective effects.
03
Biological functions
Selective nutrient absorptionProtection against pathogens and toxinsRegulation of intestinal permeabilityImmune homeostasisMicrobiota maintenance
04
Disease associations
Food allergiesMicrobial infectionsIrritable bowel syndrome (IBS)Inflammatory bowel disease (IBD)Celiac diseaseMetabolic syndromeNon-alcoholic fatty liver disease (NAFLD)DiabetesSeptic shock
05
Safety considerations
Potential for dysbiosis with antibiotic useExacerbation of inflammation with certain interventionsVariability in response to dietary interventionsLack of standardized methods for assessing intestinal permeability
06
Interacting drugs
Probiotics
6 more in the full profile.
07
Biomarkers
Zonulin levelsIntestinal fatty acid-binding protein (I-FABP)Lipopolysaccharide (LPS)IgA levelsFecal calprotectinTJs proteins expression
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