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Intestinal Smooth Muscle Cells

Molecular classification: Cell Type, Muscle Cell

Overview

Intestinal smooth muscle cells are specialized, non-striated muscle cells that form the muscular layer of the gastrointestinal tract. Their primary function is to generate coordinated contractions (peristalsis) that propel contents through the intestines. These cells are indirectly targeted by stimulant laxatives such as senna and bisacodyl, which induce bowel movements by stimulating or irritating these muscles, leading to increased contractility.

Other names: Visceral Smooth Muscle CellsGI Smooth MuscleColonic Smooth Muscle

Mechanism of action

Stimulation of enteric nerves or direct irritation leading to increased peristalsis and muscle contraction.

Biological functions

PeristalsisGastrointestinal MotilityMuscle Contraction

Disease associations

ConstipationIrritable Bowel Syndrome (IBS)Gastrointestinal Disorders

Safety considerations

Abdominal crampingDiarrheaElectrolyte imbalance (with overuse)Dehydration (with overuse)Laxative dependence (with overuse)

Interacting drugs

Senna

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