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Intestinal Water Retention via Osmotic Effect (Ascorbic Acid)
- Molecular classification
- Physiological Process, Osmosis
01
Overview
Intestinal retention of water via an osmotic effect—such as that caused by excess oral intake of ascorbic acid—is a well-characterized physiological response. It results from increased luminal osmolality due to unabsorbed molecules drawing fluid into or preventing its reabsorption from the gut. This mechanism underlies both therapeutic uses (osmotic laxatives) and side effects associated with high-dose vitamin C supplementation.
- Other names
- Ascorbic acid-induced osmotic diarrheaVitamin C induced intestinal water retentionOsmotic laxative effect of ascorbic acid
02
Mechanism of action
Unabsorbed ascorbic acid increases luminal osmolality, drawing water into the intestinal lumen and preventing its reabsorption.
03
Biological functions
Water retentionOsmotic regulationLaxation
04
Disease associations
ConstipationDiarrhea
05
Safety considerations
DiarrheaAbdominal crampingDehydration (with excessive use)
06
Interacting drugs
Ascorbic Acid (Vitamin C)
1 more in the full profile.
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