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Target intelligence / Profile preview
Intracellular Calcium Channel (ICCC)
- Target
- ICCC
- Molecular classification
- Ion channel
01
Overview
Intracellular calcium channels are specialized ion channels located on the membranes of intracellular organelles, primarily the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR). They mediate the release of calcium ions (Ca2+) from these internal stores into the cytoplasm, regulating diverse cellular processes including muscle contraction, neurotransmitter release, gene expression, and cell signaling. Major types include Ryanodine Receptors (RyR) and Inositol 1,4,5-Trisphosphate Receptors (IP3R).
- Other names
- Intracellular Ca2+ ChannelEndoplasmic Reticulum Calcium ChannelSarcoplasmic Reticulum Calcium Channel
02
Mechanism of action
Modulation of intracellular calcium release
03
Biological functions
Calcium signalingMuscle contractionNeurotransmitter releaseGene expression regulationSignal transduction
04
Disease associations
Malignant hyperthermiaCardiac arrhythmiasHeart diseaseNeurodegenerationCancer
05
Safety considerations
Potential for cardiac dysfunctionRisk of malignant hyperthermia in susceptible individualsArrhythmias
06
Interacting drugs
Ryanodine
1 more in the full profile.
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