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Intracellular Calcium Handling Pathway
- Molecular classification
- Pathway, Signaling Cascade
01
Overview
The intracellular calcium handling pathway refers to the complex network of molecular mechanisms and signaling events that regulate the concentration, movement, and effects of calcium ions (Ca²⁺) within cells. Calcium acts as a ubiquitous second messenger, controlling diverse cellular functions such as muscle contraction, neurotransmitter release, gene expression, cell proliferation, metabolism, and apoptosis.
- Other names
- Calcium Signaling PathwayIntracellular Ca2+ Homeostasis
02
Biological functions
Muscle contractionNeurotransmissionHormone secretionGene transcription regulationCell growthApoptosisMetabolism regulationSignal transductionCalcium homeostasis
03
Disease associations
Heart failureNeurodegenerative diseaseMetabolic disordersCancerCardiac dysfunctionObesity
04
Safety considerations
ExcitotoxicityPathological hypertrophyApoptosis due to aberrant activationCompromised contractility/prolonged relaxation phases
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