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Intracellular Calcium Signaling Pathway (Ca²⁺ signaling pathway)
- Target
- Ca²⁺ signaling pathway
- Molecular classification
- Signaling Pathway, Second Messenger System
01
Overview
The intracellular calcium signaling pathway is a fundamental cellular mechanism in which calcium ions (Ca²⁺) act as versatile second messengers to regulate a wide array of physiological processes. These include cell excitability, exocytosis, motility, apoptosis, gene transcription, and more. The pathway involves tightly controlled changes in cytosolic Ca²⁺ concentration through release from intracellular stores (primarily the endoplasmic reticulum [ER] and mitochondria) or influx from the extracellular space via plasma membrane channels.
- Other names
- Calcium signalingCa2+ signalingIntracellular calcium homeostasis
02
Mechanism of action
Modulation of intracellular calcium concentrations, either by affecting calcium channels, pumps, or intracellular stores.
03
Biological functions
Signal transductionCell excitabilityExocytosisMotilityApoptosisGene transcriptionMuscle contractionMetabolism
04
Disease associations
Cardiac arrhythmiasNeurodegenerationImmunodeficienciesMuscle disordersCancer progression
05
Safety considerations
Disrupted calcium homeostasis can lead to a wide range of adverse effects depending on the specific cell type and physiological context.Off-target effects on calcium signaling in unintended tissues.
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