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Intracellular loop 4 (ICL4)

Target: ICL4
Molecular classification: Intracellular loop, ABC transporter domain

Overview

The intracellular loop 4 (ICL4) of the cystic fibrosis transmembrane conductance regulator (CFTR) is a highly conserved region that plays a critical role in the structure, processing, and function of the CFTR protein. It connects the tenth and eleventh transmembrane spans of CFTR and is essential for proper folding, processing, and delivery of CFTR to the cell membrane. Mutations in this region can disrupt biosynthetic processing and impair maturation, leading to reduced functional expression at the plasma membrane. Although part of the CFTR protein, ICL4 itself is not considered a direct therapeutic target.

Biological functions

Protein foldingProtein processingCFTR traffickingChannel conductance regulationStabilizing conformational states

Disease associations

Cystic fibrosis

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