Intracellular protein synthesis via exogenous messenger RNA translation

This is not a single molecular target, but a therapeutic strategy in which exogenous mRNA is administered to cells to drive intracellular translation and production of a specific protein. The RNA is delivered via various vectors (commonly lipid nanoparticles), enters the cell by endocytosis, escapes into the cytosol, and is then translated by the cell’s ribosomes into protein. This process can be exploited for vaccination, protein replacement, or immunotherapy. It is fundamentally distinct from conventional drug targets, as it relies on the host’s translational apparatus rather than a discrete molecular receptor or enzyme.

Other names

Exogenous mRNA translationExogenous protein synthesis via mRNASynthetic mRNA-driven protein expressionmRNA-mediated protein synthesis

Delivery of exogenous mRNA to cytoplasm, using vectors such as lipid nanoparticles or electroporation. mRNA translation by ribosomes to produce encoded protein. Resultant protein executes intended therapeutic effect