Intracellular Trafficking Protein PfACG1 (None)

PfACG1 is an intracellular trafficking protein found in *Plasmodium falciparum*. It is believed to play a key role in vesicular transport and lipid body association within the parasite. Recent studies have identified mutations in the gene encoding this protein among *P. falciparum* clones resistant to novel antimalarial compounds such as MMV688533, making it a potential antimalarial drug target. Localization studies show it resides adjacent to the digestive vacuole and partially associates with neutral lipid bodies.

Other names

PfACG1Putative intracellular trafficking protein isoform 1

Unknown, but mutations in PfACG1 confer resistance to MMV688533, suggesting involvement in compound action or resistance.