Intracellular vesicle transport system phospholipid membranes

The Intracellular vesicle transport system phospholipid membranes refer to the lipid bilayers of organelles involved in the movement of proteins and lipids within the cell, such as the trans-Golgi network, endosomes, and lysosomes. These membranes are increasingly recognized as non-canonical therapeutic targets for certain drugs, particularly cationic amphiphilic drugs (CADs) like the antidepressant sertraline. Sertraline interacts with these membranes by inserting into the lipid bilayer, which alters membrane curvature and physical properties, a mechanism described by the bilayer couple hypothesis. This interaction disrupts the recruitment of essential trafficking proteins like clathrin and the activity of the vacuolar ATPase, leading to impaired vesicle formation and organelle acidification. While primarily studied in yeast as a mechanism for sertraline's antifungal activity, this target is also relevant to understanding drug-induced phospholipidosis and the secondary effects of various psychoactive medications in humans.

Other names

Vesiculogenic membranesIntracellular organelle membranesAcidic organelle membranesVesicle transport system membranes

Interaction with phospholipid membranes according to the bilayer couple hypothesis, leading to altered membrane curvature and disruption of vesicle trafficking and organelle function.