Intraflagellar transport protein 43 homolog (IFT43)

Intraflagellar transport protein 43 homolog (IFT43) is a component of the IFT-A complex, which is essential for the bidirectional movement and assembly of proteins within cilia and flagella[1][2][3]. IFT43 participates in the maintenance and structural stability of cilia, microtubule-based organelles involved in cellular signaling and development[1][2][3]. The protein forms part of the IFT-A complex, a set of six polypeptides responsible primarily for retrograde transport within cilia, carrying material from the ciliary tip back to the base[1][2]. IFT43 interacts directly with other IFT-A proteins, particularly IFT121, helping regulate both the stability and correct cellular localization of the entire IFT-A complex[2]. Disruption or loss of IFT43 leads to defective ciliogenesis, instability of the IFT-A complex, and clinical syndromes known as ciliopathies—such as cranioectodermal dysplasia (Sensenbrenner syndrome)—characterized by skeletal, kidney, liver, retinal, and ectodermal tissue abnormalities[1][2]. There are no known therapeutic drugs that directly target IFT43, and it is not currently considered a therapeutic target in pharmacology, but it is a critical factor in developmental disorders and rare genetic diseases[1][2][3].

Other names

C14orf179FLJ32173MGC16028CED3RP81SRTD18IFT complex A subunitintraflagellar transport 43 homolog