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Intraflagellar transport protein 56 (IFT56)
- Target
- IFT56
- Molecular classification
- Transporter, Ciliary protein, Intraflagellar transport complex B component
01
Overview
Intraflagellar transport protein 56 (IFT56, also known as TTC26 or DYF13) is a protein component of the intraflagellar transport (IFT) complex B, which is essential for the assembly, maintenance, and function of cilia and flagella in eukaryotic cells[2]. IFT56 mediates the transport of specific cargo proteins related to ciliary and flagellar motility, particularly the inner dynein arms and other regulatory complexes, ensuring proper ciliary beat and length. Loss or mutation of IFT56 leads to shortened and dysfunctional cilia and flagella, causing diverse developmental and organ defects, as demonstrated in zebrafish, mice, and algae models[2]. IFT56 is believed to act as an adaptor within the IFT-B complex and is a peripheral, but not core, IFT-B component. There is currently no evidence that IFT56 is a direct therapeutic target or that drugs have been developed to modulate its function. Its primary importance is in research on ciliary biology and diseases resulting from ciliary dysfunction.
- Other names
- TTC26DYF13
02
Biological functions
Assembly and maintenance of cilia/flagellaTransport of motility-related proteins (especially inner dynein arms and associated regulatory complexes) into cilia/flagellaRegulation of ciliary/flagellar length
03
Disease associations
Ciliopathies (e.g., defects associated with cilia formation and function)Developmental disorders (e.g., left–right asymmetry, pronephric cysts, eye, ear, and kidney defects in model organisms)
04
Safety considerations
Mutations or knockdown may impair cilia and flagella function or assembly, leading to developmental abnormalitiesShort or immotile cilia/flagella can result from defective IFT56 function
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