Intraflagellar transport protein 70 homolog B (IFT70B)

Intraflagellar transport protein 70 homolog B (IFT70B) is a tetratricopeptide repeat (TPR)-containing protein that is a component of the IFT-B complex, part of the intraflagellar transport (IFT) system essential for assembly and maintenance of cilia in eukaryotic cells[2][1]. IFT-B proteins―including IFT70B―compose the backbone of anterograde IFT trains, which transport structural and signaling cargo along the axoneme toward the ciliary tip[2][3]. IFT70B, together with other IFT-B proteins such as IFT88 and IFT52, forms the structural core that interacts tightly and helps organize large protein cargos for delivery into the cilium[2]. Disruption of IFT70B or other subunits in the IFT-B complex results in defective ciliogenesis and is associated with a growing spectrum of human genetic diseases called ciliopathies[4][6]. No direct pharmacological targeting or drug interactions are known for IFT70B, and its primary importance lies in its fundamental scaffolding and transport role in the cilium biogenesis machinery.

Other names

IFT70Bintraflagellar transport 70BTPR-containing protein IFT70B