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Intraflagellar transport protein 74 homolog (IFT74)
- Target
- IFT74
- Molecular classification
- Other, Transport protein, Ciliary transport complex (IFT-B complex component), Coiled-coil protein
01
Overview
Intraflagellar transport protein 74 homolog (IFT74) is a core component of the IFT-B complex, essential for the assembly and function of motile and primary cilia. IFT74, often forming a heterodimer with IFT81, facilitates the binding and transport of tubulin and other cargo along axonemal microtubules for ciliogenesis. Mutations in IFT74 are implicated in a range of ciliopathies affecting development, organ function, and ciliary motility, including Joubert syndrome, Bardet–Biedl syndrome, and certain neurodegenerative disorders[1][2][4][3][6]. IFT74 is not considered a traditional drug target but is a vital structural and functional player in cellular ciliary biology.
- Other names
- Capillary morphogenesis gene 1 proteinCoiled-coil domain-containing protein 2CMG1CMG-1FLJ22621BBS22JBTS40SPGF58CCDC2intraflagellar transport protein 74 homologcapillary morphogenesis gene 1 proteincapillary morphogenesis protein 1coiled-coil domain containing 2
02
Biological functions
CiliogenesisCiliary protein transportTubulin transportCiliary assembly and maintenance
03
Disease associations
Ciliopathies (including Joubert syndrome 40, Bardet–Biedl syndrome, skeletal ciliopathies)Neurodegenerative disease (amyotrophic lateral sclerosis–frontotemporal dementia)Male infertility (due to ciliary/flagellar dysfunction)
04
Safety considerations
Loss of function mutations can lead to primary or motile ciliopathies, with defects affecting multiple organ systems
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