Intraflagellar transport protein 80 homolog (IFT80)

Intraflagellar transport protein 80 homolog (IFT80) is a key structural component of the intraflagellar transport-B (IFT-B) complex, which is essential for the assembly and maintenance of cilia and flagella, critical organelles for cellular motility, sensory perception, and developmental signaling[1][2][3][4][5]. IFT80 comprises multiple WD40 repeat domains that form β-propeller structures, enabling it to mediate interactions within the IFT-B complex—primarily via IFT38—and to promote higher-order complex formation through homo-dimerization[1][3][5]. Changes in this protein, especially loss-of-function mutations, disrupt normal ciliogenesis and are directly associated with human genetic disorders, most notably Jeune asphyxiating thoracic dystrophy and short rib polydactyly type III, which manifest with skeletal abnormalities and multisystem malformations[5]. IFT80 also plays a role in osteogenesis, partly through modulation of the Hedgehog-Gli signaling pathway[5]. No pharmacological agents are currently known to act directly on IFT80, and given its crucial role in a core cellular process, it is not considered a conventional drug target.

Other names

Intraflagellar transport protein 80 homologIFT80WD repeat-containing protein 56WDR56KIAA1374FAP167CFAP167ATD2SRTD2

Not applicable (no approved or investigational drugs are known to act directly on IFT80).