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Target intelligence / Profile preview
Invariant Natural Killer T Cells (iNKT)
- Target
- iNKT
- Molecular classification
- Lymphocyte, Innate-like lymphocyte, T cell subset, TCR-expressing cell
01
Overview
Invariant natural killer T cells (iNKT cells) are a unique subset of lymphocytes that bridge innate and adaptive immunity. They display properties of both conventional T cells and natural killer (NK) cells, allowing them to respond rapidly to immune challenges. iNKT cells are defined by their semi-invariant antigen receptor recognizing lipid antigens via CD1d, capable of rapid effector responses that shape both innate and adaptive immunity across multiple tissues.
- Other names
- Type I NKT cellsClassical NKT cells
02
Mechanism of action
N/A
03
Biological functions
Immune responseCytokine secretionCytotoxicityImmune regulationB cell modulationInflammation modulationTissue homeostasis
04
Disease associations
CancerInfectionAutoimmunityMetabolic disease
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