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IQ domain-containing protein F2 (IQCF2)

Target: IQCF2
Molecular classification: Other (contains an IQ motif, classically associated with calmodulin-binding proteins)

Overview

IQ domain-containing protein F2 (IQCF2) is a protein encoded by the *IQCF2* gene, characterized by the presence of an IQ motif—a sequence known for binding calmodulin, a calcium sensor protein[6][2]. While proteins containing IQ motifs play established roles in calcium signaling and regulation of the cytoskeleton in many organisms[1][2][3], the specific biological function of IQCF2 in humans remains undefined. Proteomic evidence shows expression in the hippocampal formation in humans[5], but there is no information indicating it acts as a receptor, enzyme, transporter, or known drug target. No interacting drugs, mechanisms of action, or established disease associations have been reported. IQCF2 should not be confused with similarly named bacterial proteins such as "protein F2" in *Streptococcus pyogenes*, which is unrelated[4].

Other names: IQ motif containing F2IQCF2IQ domain-containing protein F2

Mechanism of action

none known

Biological functions

Other (function is largely unknown in humans; in plants, related IQ domain proteins act as hubs in calcium signaling and cytoskeletal organization[1][3])

Disease associations

Other (no established disease association for IQCF2 in current literature)

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