IQ domain-containing protein M (IQCM)

IQ domain-containing protein M (IQCM) is part of the plant IQM gene family, which encodes proteins with a single IQ motif—a short alpha-helical consensus sequence enabling calcium-independent binding to calmodulin[2]. In plants like soybean and Arabidopsis, IQCM proteins are typically nuclear (occasionally cytoplasmic or chloroplastic) and may regulate cellular events through modulating calmodulin-dependent processes, but are not widely studied outside plant biology[2]. There is no evidence that IQCM acts as a receptor, enzyme, transporter, transcription factor, or other conventional drug target in humans[2]. The “IQ motif” is broadly distributed in many proteins, mainly contributing to calmodulin signaling and cytoskeletal regulation, but the IQCM molecule itself is defined narrowly and without disease or therapeutic implications in current biomedical literature[2][1]. If targeting human or disease-relevant IQ motif proteins, be aware that “IQ motif containing M” may be easily confused with other proteins (e.g., IQGAPs, IQCH), none of which map to IQCM. This entry should be flagged as inaccurate when seeking targets for drug discovery or human therapeutics.

Other names

IQ motif containing MIQCMIQ domain-containing protein MIQM (used generically for the plant IQM family)

Not applicable; no drug mechanism described for this protein.