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Target intelligence / Profile preview
IQCH antisense RNA 1 (IQCH-AS1)
- Target
- IQCH-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
IQCH antisense RNA 1 (IQCH-AS1) is a long non-coding RNA transcribed antisense to the protein-coding IQCH gene. It has been shown to modulate cellular pathways by acting as a competing endogenous RNA (ceRNA), particularly sponging miR-196a-5p and impacting the expression of PPP2R1B. In thyroid cancer, IQCH-AS1 is significantly downregulated, and its overexpression increases the sensitivity of cancer cells to doxorubicin, highlighting a potential role in chemoresistance. IQCH-AS1 is correlated with cancer patient survival and may serve as a biomarker for diagnosis and prognosis in oncology, especially in thyroid cancer[6][5]. There is no evidence that IQCH-AS1 encodes a protein or functions as a receptor, enzyme, transporter, or conventional therapeutic target molecule[6][5][7].
- Other names
- IQCH antisense RNA 1 (non-protein coding)IQCH-AS1
02
Mechanism of action
Modulation of gene expression via ceRNA mechanism (sponging miR-196a-5p and regulating PPP2R1B expression)
03
Biological functions
Regulation of gene expressionChemosensitivity modulationCompeting endogenous RNA activityOther
04
Disease associations
CancerChemoresistanceOther
05
Interacting drugs
Doxorubicin
06
Biomarkers
IQCH-AS1 expression (prognostic and diagnostic marker in thyroid cancer)
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