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Target intelligence / Profile preview
IRDye 800CW
- Target
- IRDye 800CW
- Molecular classification
- Other (Near-infrared fluorescent dye)
01
Overview
IRDye 800CW is a highly water-soluble, synthetic near-infrared fluorescent dye (excitation: 773–785 nm; emission: 792–803 nm) widely used for labeling antibodies, peptides, and small molecules for imaging applications in vitro, in vivo, and in preclinical studies[1][3][6][7][8]. Its strong NIR fluorescence allows for deep tissue penetration and low background in optical imaging. It is available in reactive forms such as NHS ester or maleimide to enable conjugation to amines or thiols, respectively[3][8]. IRDye 800CW is not itself a therapeutic target, but it is pivotal in research and diagnostics when attached to biomolecules[1][2][3][6][8].
- Other names
- IRDye 800CWIRDye® 800CW800CWIRDye 800CW NSH EsterIRDye 800CW MaleimideIRDye 800CW Carboxylate
02
Biological functions
Other (Imaging, labeling, detection in biochemical and cell-based assays—does not participate in biological functions or signaling)
03
Disease associations
Other (Used diagnostically and in research imaging in disease models, including cancer and infection, but not itself a disease mediator or target)
04
Safety considerations
Some studies note potential for retention or background effects in vivo or tissue, mostly relevant for imaging assay interpretation and not direct toxicity
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