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Target intelligence / Profile preview
Iron Accumulation in Neurons
- Molecular classification
- Other
01
Overview
Iron accumulation in neurons refers to the pathological buildup of iron within neuronal cells, a phenomenon observed in normal aging and various neurodegenerative diseases. While iron is essential for numerous cellular processes, its dysregulation can lead to oxidative stress and neuronal damage. Several mechanisms contribute to abnormal neuronal iron buildup, including increased uptake/reduced export, sequestration, and metabolic disturbances. Reducing excessive neuronal/labile brain iron using chelators capable of crossing the blood-brain barrier has shown promise experimentally.
- Other names
- Neuronal Iron OverloadBrain Iron AccumulationExcessive Neuronal Iron
02
Mechanism of action
Chelation of iron to reduce oxidative stress and neurodegeneration
03
Biological functions
Oxygen transportMitochondrial respirationMyelin synthesisNeurotransmitter metabolismOxidative stressCell death
04
Disease associations
Neurodegenerative diseaseAlzheimer's DiseaseParkinson's DiseaseNeurodegeneration with Brain Iron Accumulation (NBIA)Aging-related cognitive decline
05
Safety considerations
Systemic iron deficiencyBlood-brain barrier penetration of chelatorsOff-target effects of chelators
06
Interacting drugs
Brain-permeable chelators
07
Biomarkers
Regional brain iron levels (MRI)
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