Target intelligence / Profile preview

Iron Deficiency (IDA)

Target
IDA
Molecular classification
Nutritional Deficiency, Hematological Disorder
01

Overview

Iron deficiency is a condition resulting from inadequate iron levels in the body, leading to impaired hemoglobin synthesis and reduced oxygen transport. It is a common cause of anemia, characterized by fatigue, weakness, and other symptoms. The condition arises from insufficient dietary intake, increased iron requirements, malabsorption, or chronic blood loss. Diagnosis involves assessing iron stores and blood parameters. Treatment includes oral or intravenous iron supplementation, addressing underlying causes of blood loss, and dietary modifications. Hepcidin regulation plays a crucial role in iron homeostasis and is a target for investigational therapies.

Other names
Iron-Deficiency AnemiaSideropenia
02

Mechanism of action

Iron supplements replenish iron stores, enabling increased hemoglobin production and improved oxygen carrying capacity. Hepcidin modulators (investigational) aim to restore iron availability by reducing hepcidin levels and promoting iron release from stores and increasing intestinal absorption.

03

Biological functions

Oxygen Transport ImpairmentHemoglobin Synthesis DeficiencyRed Blood Cell DysfunctionIron Metabolism Disruption
04

Disease associations

AnemiaFatigueCardiovascular StressImpaired Growth and Development (in children)Pregnancy Complications
05

Safety considerations

Oral Iron Supplement Side Effects (gastrointestinal distress, constipation)Intravenous Iron Supplement Side Effects (anaphylaxis, hypersensitivity reactions)Iron Overload (Hemochromatosis, Hemosiderosis) - rare, but possible with excessive supplementationDrug Interactions (e.g., with antacids, proton pump inhibitors, certain antibiotics)
06

Interacting drugs

Oral Iron Supplements (Ferrous Sulfate, Ferrous Gluconate, Ferrous Fumarate)

2 more in the full profile.

07

Biomarkers

Serum Ferritin (low)Serum Iron Concentration (low)Total Iron-Binding Capacity (TIBC) (high)Transferrin Saturation (low)Hemoglobin Levels (low)Red Blood Cell Count (low)Hematocrit (low)

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