Target intelligence / Profile preview

Iron Stores

Molecular classification
Other
01

Overview

Iron stores refer to the body's reserve of iron, primarily maintained in specialized storage proteins such as ferritin and hemosiderin, as well as within the labile iron pool. These stores are essential for regulating systemic iron homeostasis, supporting critical biological functions such as oxygen transport, DNA synthesis, energy production, and cell growth. Regulation is achieved via the hepcidin-ferroportin axis and IRP/IRE system. Disorders related to abnormal iron stores include iron deficiency anemia and iron overload syndromes like hemochromatosis.

Other names
Body Iron StoresStored IronIron StorageIron Homeostasis
02

Mechanism of action

Varies depending on the specific component involved. For example, iron supplements increase iron levels, while iron chelators bind to and remove excess iron. Hepcidin mimetics can reduce iron absorption and release.

03

Biological functions

Iron homeostasisIron storageRegulation of iron absorptionRegulation of iron release
04

Disease associations

Iron deficiency anemiaHemochromatosisIron overload syndromesAnemia of chronic disease
05

Safety considerations

Iron overload (toxicity)Adverse effects of iron supplementation (e.g., gastrointestinal issues)Chelator-related side effectsHepcidin mimetic-related side effects
06

Interacting drugs

Iron supplements

3 more in the full profile.

07

Biomarkers

Serum ferritinTransferrin saturationHemoglobinHematocritSerum ironTotal iron-binding capacity (TIBC)

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