Iron homeostasis pathways (null)

Iron homeostasis pathways comprise the coordinated regulation of iron uptake (e.g., transferrin receptor 1, DMT1), storage (ferritin), export (ferroportin), and systemic control (hepcidin, BMP/SMAD signaling), as well as cellular regulators (iron regulatory proteins IRP1/2, iron responsive elements)[1][2][5][6]. This network ensures adequate iron for hemoglobin, myoglobin, DNA synthesis, and mitochondrial respiration, while preventing iron overload and toxicity[1][6]. Key regulatory circuits include the **hepcidin–ferroportin axis** for systemic control and the **IRP/IRE system** for cellular regulation[2]. Disruption is implicated in anemia, hemochromatosis, infections, cancer, and neurodegeneration[1][2][4]. To obtain structured information, you must specify a particular molecular component (e.g., "Hepcidin," "Ferroportin," "Transferrin receptor 1") within the iron homeostasis pathways. "Iron homeostasis pathways" as a term describes a complex biological process, not a single druggable target.

Other names

Iron regulation pathwaysIron metabolism pathwaysIron regulatory network

Not applicable for the overall pathway. For components: Iron chelation (removal of excess iron); Modulation of hepcidin-ferroportin signaling (altering iron export); Blocking or enhancing iron uptake via transferrin or divalent metal transporter 1 (DMT1); Alteration of iron storage/ferritin metabolism