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Target intelligence / Profile preview
Iron Ion Homeostasis
- Molecular classification
- Homeostatic Process
01
Overview
Iron ion homeostasis refers to the tightly regulated processes that maintain a steady state of iron ions within cells and throughout the body. This regulation ensures sufficient iron is available for essential biological functions, such as oxygen transport and DNA synthesis, while preventing toxic accumulation that can cause oxidative damage. Key regulators include hepcidin, ferroportin, the IRP/IRE system, and HIFs. Dysregulation leads to anemia or hemochromatosis.
02
Mechanism of action
Varies depending on the specific intervention (e.g., iron supplementation increases iron levels, iron chelation removes excess iron). Hepcidin mimetics reduce iron release from cells.
03
Biological functions
Maintenance of iron ion steady stateErythropoiesis supportMitochondrial respiration supportImmune function supportRegulation of iron absorptionRegulation of iron storageRegulation of iron transport
04
Disease associations
AnemiaHemochromatosisIron deficiencyIron overloadInflammation
05
Safety considerations
Iron overload (toxicity)Iron deficiency (anemia)Drug interactions (e.g., with iron supplements)Gastrointestinal side effects (iron supplements)Risk of infection (iron overload)
06
Interacting drugs
Iron supplements
3 more in the full profile.
07
Biomarkers
Serum ironTransferrin saturationSerum ferritinHepcidin levelsHemoglobinRed blood cell countSoluble transferrin receptor (sTfR)
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