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Target intelligence / Profile preview
Iron-regulated surface determinant protein B (IsdB)
- Target
- IsdB
- Molecular classification
- Bacterial surface protein, Substrate-binding protein (partner to ABC transporter systems), Receptor (for hemoproteins, vitronectin, and von Willebrand factor), Virulence factor
01
Overview
Iron-regulated surface determinant protein B (IsdB) is a 75 kDa cell surface protein of *Staphylococcus aureus* that plays dual roles in iron acquisition and host colonization. Under iron starvation, IsdB is highly expressed and mediates uptake of heme from hemoglobin, providing essential iron for bacterial growth[5]. Additionally, IsdB acts as a receptor for host proteins such as vitronectin and von Willebrand factor, facilitating adherence and invasion into host tissues. These properties make IsdB a critical virulence factor and an attractive target for therapeutic intervention, notably through monoclonal antibodies, which have shown protective activity in animal models[6].
- Other names
- IsdBIron-regulated surface determinant BStaphylococcal hemoglobin receptor
02
Mechanism of action
For monoclonal antibodies: inhibition of IsdB-mediated heme acquisition, opsonophagocytic killing, and inhibition of virulence. Potential interference with bacterial adhesion by blocking IsdB binding sites
03
Biological functions
Iron acquisition (heme uptake from hemoglobin)Host cell adhesion (binding to vitronectin and von Willebrand Factor)Immune evasionMediation in pathogenesis (enabling *S. aureus* to persist and invade host tissues)
04
Disease associations
Infection (essential for *S. aureus* virulence)Inflammatory response (activates host immunity via TLR2)
05
Safety considerations
Addressing bacterial iron acquisition may lead to selective pressure, possible resistance or compensatory mechanisms in bacteriaTargeting surface proteins could theoretically trigger autoimmunity if host mimicry is present, though not specifically reported for IsdB
06
Interacting drugs
Monoclonal antibodies targeting IsdB have demonstrated protective effects in preclinical models
1 more in the full profile.
07
Biomarkers
None directly reported for patient selection or efficacy, but IsdB expression is strongly upregulated during iron starvation and infection
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