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Target intelligence / Profile preview
Ferroportin (FPN)
- Target
- FPN
- Molecular classification
- Transporter, Major facilitator superfamily (MFS) transporter
01
Overview
Ferroportin is a transmembrane protein and the only known cellular iron exporter in humans. It is encoded by the SLC40A1 gene. Ferroportin plays a central role in systemic iron homeostasis by transporting iron from inside cells to the outside, enabling its release into the bloodstream. Its activity is tightly regulated by hepcidin, which binds to ferroportin and triggers its internalization and degradation.
- Other names
- Solute carrier family 40 member 1SLC40A1Iron-regulated transporter 1IREG1
02
Mechanism of action
Hepcidin binds to ferroportin, causing its internalization and degradation, thus inhibiting iron export.
03
Biological functions
Iron exportIron homeostasisDietary iron absorptionIron recyclingIron transport
04
Disease associations
Ferroportin diseaseHereditary hemochromatosisAnemiaIron overloadCardiac dysfunction
05
Safety considerations
Dysregulation of iron homeostasisIron overloadAnemiaCardiac dysfunction
06
Interacting drugs
Hepcidin
07
Biomarkers
Ferroportin levelsHepcidin levelsSerum ironTransferrin saturationFerritin
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