Iron-sulfur cluster assembly 2 pseudogene 1 (ISCA2P1)

Iron-sulfur cluster assembly 2 pseudogene 1 (ISCA2P1) is classified as a pseudogene related to the iron-sulfur cluster assembly protein family. Unlike the functional ISCA2 gene, which encodes a protein involved in the mitochondrial iron-sulfur cluster biogenesis necessary for proper assembly of Fe–S proteins[1], ISCA2P1 does not code for a functional protein and is not implicated in any biological processes or diseases. It is annotated in gene databases solely as a non-coding, non-functional genomic segment. The functional ISCA2 gene (not ISCA2P1) is involved in mitochondrial iron–sulfur cluster assembly machinery, which is essential for cellular respiration and other metabolic processes[1]. Only ISCA2—not ISCA2P1—is an enzyme and potential drug target, particularly in metabolic or mitochondrial disorders, but this is not applicable for the pseudogene ISCA2P1. ISCA2P1 is a non-functional pseudogene and not a molecular target of therapeutic, diagnostic, or pharmacological relevance. All canonical naming, annotation, and biological function assignments should be redirected to the functional gene ISCA2 where relevant, and ISCA2P1 should not be included in lists of druggable targets or biological markers.

Other names

ISCA2P1iron-sulfur cluster assembly 2 pseudogene 1

None (as no drugs act on this pseudogene).