Target intelligence / Profile preview

Iron Supplementation (Elemental Replacement) (None)

Target
None
Molecular classification
Mineral Supplement
01

Overview

Iron supplementation (elemental replacement) refers to the administration of iron, primarily as a mineral supplement, to correct or prevent iron deficiency and replenish body iron stores. This is most commonly used in the treatment of iron deficiency anemia (IDA), but may also be indicated for non-anemic individuals with depleted iron reserves. It provides elemental iron to support hemoglobin synthesis, oxygen transport, hormone production, and overall cellular metabolism. Oral and intravenous formulations are available, with oral forms being the first-line treatment. Dosage is typically 50-200 mg/day of elemental iron, administered for 3-12 weeks. Adverse effects can include gastrointestinal upset with oral forms and hypersensitivity reactions with intravenous forms. Monitoring of iron levels and potential toxicity is crucial.

Other names
Ferrous sulfateFerrous gluconateFerrous fumarateIron bisglycinateIron protein succinylate
02

Mechanism of action

Provides elemental iron to replenish iron stores and support hemoglobin synthesis.

03

Biological functions

Hemoglobin synthesisOxygen transportHormone productionImmune functionCognitive performanceCellular metabolism
04

Disease associations

Iron deficiency anemiaLow ferritin/iron storesPregnancyHeavy menstrual bleedingMalabsorption syndromes
05

Safety considerations

Gastrointestinal side effects (nausea, abdominal pain, constipation/diarrhea)Dark stoolsAltered gut microbiotaHypersensitivity reactions/anaphylaxis (IV iron)Hypophosphatemia (IV iron)Increased infection risk (IV iron)Toxicity (vomiting, convulsions, peptic ulcers)Hemosiderosis/Hemochromatosis
06

Interacting drugs

Ferrous sulfate

4 more in the full profile.

07

Biomarkers

Hemoglobin levelsFerritin levelsIron stores

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