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Target intelligence / Profile preview
Iron surface determinant B protein (IsdB)
- Target
- IsdB
- Molecular classification
- Cell wall-anchored surface receptor, NEAT domain-containing protein
01
Overview
Iron surface determinant B protein (IsdB) is a cell wall-anchored surface receptor produced by Staphylococcus aureus. It plays a crucial role in iron acquisition from host hemoglobin and mediates adhesion to host tissues. IsdB contains two NEAT domains responsible for binding heme and vitronectin, contributing to bacterial survival and virulence during infection.
02
Mechanism of action
Inhibition of heme acquisition, disruption of host cell adhesion
03
Biological functions
Heme acquisitionIron acquisitionHost protein binding (Vitronectin)Adhesion to host cells
04
Disease associations
InfectionStaphylococcus aureus infectionVirulence
05
Safety considerations
Potential for off-target effects on host proteins due to structural similarities
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