Target intelligence / Profile preview

Iron Transport System (N/A)

Target: N/A
Molecular classification: Transporter, Receptor, Enzyme, Hormone

Overview

The iron transport system is a complex network of proteins and pathways responsible for the uptake, distribution, storage, and export of iron. It involves key components like transferrin, transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferroportin, and hepcidin. Dysregulation of this system leads to various iron-related disorders, making it a significant therapeutic target.

Other names: Iron MetabolismIron HomeostasisIron Trafficking

Mechanism of action

Regulation of iron absorption, transport, storage, and utilization.

Biological functions

Iron uptakeIron transportIron storageIron exportErythropoiesisRegulation of iron homeostasis

Disease associations

AnemiaHereditary HemochromatosisIron OverloadAnemia of Chronic DiseaseInfectionNeurodegenerative Diseases (e.g., Parkinson's, Alzheimer's)Restless Leg Syndrome

Safety considerations

Iron overloadIron deficiencyDrug-induced liver injury (DILI) (e.g., with iron chelators)Increased risk of infection (with iron supplementation in certain contexts)Cardiovascular complications (with excessive ESAs)

Interacting drugs

Iron supplements

4 more in the full profile.

Biomarkers

Serum ironTransferrin saturationSerum ferritinHepcidin levelsTransferrin Receptor 1 (TfR1) levelsDMT1 expressionFerroportin expression

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