IRX2 divergent transcript (IRX2-DT)

IRX2 divergent transcript (IRX2-DT) is a human long non-coding RNA gene located on chromosome 5 near the IRX2 protein-coding gene. It is classified as a divergent transcript, meaning it is found within 300–500 nucleotides of a protein coding gene and transcribed in the opposite direction. While some basic molecular function annotation (protein binding) exists, its biological role, disease association, and relevance as a therapeutic target are not established. The numerous aliases stem from its genomic neighbourhood (e.g., IRX2 neighbor, C5orf38) and historical annotation, but the gene is presently defined as non-coding and does not encode an active receptor, enzyme, or protein. No therapeutics, biomarkers, or clinical safety issues are associated with IRX2-DT. IRX2-DT is a long non-coding RNA and is not considered a receptor or canonical therapeutic target. The current nomenclature includes repeats and ambiguous or incorrect synonyms; only the established lncRNA name applies. There is no evidence for drug interaction or disease role in curated sources.

Other names

C5orf38CEIIRX2NBIRX2 neighborcoordinated expression to IRX2Protein CEI

None — no mechanisms are described as IRX2-DT is not targeted by drugs.