ISL1 divergent transcript (ISL1-DT)

ISL1 divergent transcript (ISL1-DT) is a gene that codes for a long non-coding RNA. It is located in close genomic proximity to the ISL1 gene and is transcribed from the opposite strand. ISL1-DT is classified as a divergent lncRNA, meaning it is not translated into a protein. Its expression pattern closely mirrors that of ISL1 in certain tissues, but ISL1-DT is consistently found at lower abundance. Current evidence suggests that ISL1-DT may be involved in the regulatory landscape around the ISL1 locus, with potential co-regulation mechanisms mediated through shared or adjacent promoter regions and chromatin interactions; however, its precise biological function and role in disease are not well characterized, and it is not established as a therapeutic target[5][4].

Other names

ISL1-DTISL1 divergent transcript