Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Islet Amyloid Polypeptide (IAPP)
- Target
- IAPP
- Molecular classification
- Peptide hormone, Calcitonin gene-related peptide family
01
Overview
Islet Amyloid Polypeptide (IAPP), also known as Amylin, is a 37-amino acid peptide hormone co-secreted with insulin from pancreatic β-cells. It plays a role in glucose homeostasis by inhibiting glucagon secretion, slowing gastric emptying, and promoting satiety. In type II diabetes, IAPP can aggregate into amyloid fibrils, leading to islet amyloidosis and contributing to β-cell dysfunction and death. It is encoded by a gene on chromosome 12p12.1 and belongs to the calcitonin gene-related peptide family.
- Other names
- Amylin
02
Mechanism of action
N/A
03
Biological functions
Glycemic regulationInhibition of glucagon releaseSlowing of gastric emptyingPromotion of satietyRegulation of glucose utilization/glycogen deposition
04
Disease associations
Type II Diabetes MellitusIslet amyloidosisCardiovascular complications (associated with Type II Diabetes)Type I Diabetes (potential involvement)
05
Safety considerations
Amyloid fibril formation and depositionβ-cell toxicityPotential for inflammasome activation, ER stress, ROS generation, membrane disruption
Beyond the preview
Go deeper on Islet Amyloid Polypeptide (IAPP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Islet Amyloid Polypeptide (IAPP).