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Target intelligence / Profile preview
Islet Amyloid Polypeptide Receptor (Amylin Receptor)
- Target
- Amylin Receptor
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The islet amyloid polypeptide receptor, also known as the amylin receptor, is a G protein-coupled receptor complex that mediates the physiological and pathological effects of islet amyloid polypeptide (IAPP), also known as amylin. It consists of a calcitonin receptor (CTR) core protein complexed with one of several possible Receptor Activity-Modifying Proteins (RAMPs). The amylin receptor plays key roles in metabolic regulation and has been implicated in both type 2 diabetes mellitus (T2DM) and neurodegenerative diseases such as Alzheimer’s disease.
- Other names
- IAPP Receptor
02
Mechanism of action
Amylinomimetic drugs like pramlintide act on these receptors to regulate glucose homeostasis.
03
Biological functions
Signal transductionRegulation of blood glucose levelsInhibition of glucagon secretionRegulation of gastric emptyingPromotion of satiety
04
Disease associations
Type 2 Diabetes MellitusAlzheimer's DiseaseNeurodegenerative diseaseMetabolic disease
05
Safety considerations
Potential for hypoglycemia with amylinomimetics.Excessive activation by aggregated peptides may lead to apoptotic cell death.
06
Interacting drugs
Pramlintide
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