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Islets of Langerhans
- Molecular classification
- Microorgan, Endocrine Tissue
01
Overview
The Islets of Langerhans are clusters of endocrine cells within the pancreas, accounting for about 1–2% of the organ’s total mass. They play a central role in glucose metabolism and whole-body energy homeostasis by secreting hormones directly into the bloodstream. These islets contain several types of hormone-producing cells (beta, alpha, delta, and PP cells) arranged in a complex network. Dysfunction or loss of β-cell mass/function leads to diabetes mellitus.
- Other names
- Pancreatic Isletsinsulae pancreaticae
02
Mechanism of action
Regulation of glucose metabolism through hormone secretion (insulin, glucagon, somatostatin, pancreatic polypeptide)
03
Biological functions
Endocrine regulationBlood sugar controlGlucose homeostasisHormone secretion
04
Disease associations
Diabetes mellitusHyperglycemiaHypoglycemia
05
Safety considerations
Hypoglycemia (with insulin therapy)Hyperglycemia (with glucagon resistance)Autoimmune destruction of beta cells (Type 1 diabetes)
06
Interacting drugs
GLP-1 receptor agonists
1 more in the full profile.
07
Biomarkers
Insulin levelsGlucagon levelsSomatostatin levelsPancreatic polypeptide levelsBlood glucose levels
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