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Target intelligence / Profile preview
Iso-glutaminyl cyclase (QPCTL)
- Target
- QPCTL
- Molecular classification
- Enzyme, Zinc-dependent metalloenzyme
01
Overview
Iso-glutaminyl cyclase (QPCTL), also known as glutaminyl-peptide cyclotransferase-like protein or isoQC, is a zinc-dependent enzyme that catalyzes the intramolecular cyclization of N-terminal glutamine and glutamic acid residues into pyroglutamate (pGlu) at the N-terminus of proteins. This post-translational modification, called pyroglutamylation, influences protein stability and function. QPCTL plays a critical role in the maturation of chemokines and the CD47 "don't-eat-me" signal, impacting immune evasion by tumor cells. Targeting QPCTL offers therapeutic opportunities in cancer immunotherapy and inflammatory diseases.
- Other names
- Glutaminyl-peptide cyclotransferase-like proteinisoQC
02
Mechanism of action
Inhibition of iso-glutaminyl cyclase activity, preventing pyroglutamylation of target proteins
03
Biological functions
Protein maturationProtein stabilizationChemokine regulationImmune checkpoint modulationProteolysis regulation
04
Disease associations
CancerInflammationNeurodegenerative diseaseAtherosclerosis
05
Biomarkers
QPCTL expression levels as a prognostic marker in cancerQPCTL expression as a predictor of response to anti-PD-L1 immunotherapy
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