Target intelligence / Profile preview

Isoamyl acetate-hydrolyzing esterase 1 (IAH1)

Target: IAH1
Molecular classification: Enzyme, Carboxylic-ester hydrolase, Hydrolase (EC 3.1.1.–)

Overview

Isoamyl acetate-hydrolyzing esterase 1 (IAH1) is an enzyme classified as a carboxylic-ester hydrolase that catalyzes the hydrolysis of short-chain esters, specifically from acetate (C2) up to hexanoate (C6). Its activity is best described in yeast (Saccharomyces cerevisiae), where it hydrolyzes isoamyl acetate, an ester contributing to fruity aroma. In humans, IAH1 is a protein-coding gene with predicted hydrolase activity, likely involved in lipid catabolic processes through its action on ester bonds. Disease associations include certain inflammatory and metabolic disorders, but it is not currently established as a therapeutic or drug-targeted protein.

Other names: Isoamyl acetate hydrolyzing esterase 1 homologIAH1testicular tissue protein Li 92

Biological functions

Lipid catabolic processHydrolysis of short-chain acetate esters (e.g., from acetate to hexanoate)Ester bond hydrolysis

Disease associations

Inflammatory skin and bowel disease, Neonatal3-methylglutaconic aciduria, type I

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